(R)-4-chlorophenyl glycine
(R)-Amino-(4-chlorophenyl)acetic acid
CAS: 43189-37-3
Molecular Formula: C8H8ClNO2
(R)-4-chlorophenyl glycine - Names and Identifiers
| Name | (R)-Amino-(4-chlorophenyl)acetic acid |
| Synonyms | H-D-Phg(4-Cl)-OH (R)-4-chlorophenylgycine (R)-4-chlorophenyl glycine D(-)-4-Chlorophenylglycine (R)-2-(4-Chlorophenyl)glycine (R)-Amino-(4-chlorophenyl)acetic acid (2R)-amino(4-chlorophenyl)ethanoic acid (R)-2-amino-2-(4-chlorophenyl)acetic acid (2R)-2-amino-2-(4-chlorophenyl)acetic acid |
| CAS | 43189-37-3 |
| InChI | InChI=1/C8H8ClNO2/c9-6-3-1-5(2-4-6)7(10)8(11)12/h1-4,7H,10H2,(H,11,12)/t7-/m1/s1 |
(R)-4-chlorophenyl glycine - Physico-chemical Properties
| Molecular Formula | C8H8ClNO2 |
| Molar Mass | 185.61 |
| Density | 1.392±0.06 g/cm3(Predicted) |
| Melting Point | 272-274 °C |
| Boling Point | 328.8±32.0 °C(Predicted) |
| Flash Point | 152.7°C |
| Vapor Presure | 7.45E-05mmHg at 25°C |
| pKa | 1.81±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.603 |
(R)-4-chlorophenyl glycine - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
(R)-4-chlorophenyl glycine - Introduction
(R)-Amino-(4-chlorophenyl)acetic acid ((R)-Amino-(4-chlorophenyl)acetic acid) is an organic compound whose structure contains-CH2COOH and-Cl groups.
The properties of the compound are as follows:
Appearance: White crystalline powder
Molecular formula: C8H8ClNO2
Molecular weight: 185.61g/mol
Melting point: 145-150°C
Solubility: Soluble in water and alcohol solvents, insoluble in non-polar solvents
(R)-Amino-(4-chroophenyl) acetic acid is mainly used in the field of medicine. It is a chiral amino acid, which is used as a raw material or stereoselective reagent in the synthesis of drugs, pharmaceutical intermediates and tablets.
The method of preparing (R)-Amino-(4-chlorophenyl)acetic acid can be achieved by the following steps:
1. Synthesis of amino acids: first, the corresponding reaction of 4-chloroacetophenone and phosgene occurs to generate 4-chloroacetophenone. This compound is then reacted with glycine under basic conditions to give the precursor compound of (R)-Amino-(4-chroophenyl) acetic acid.
2. Stereoselective conversion: The stereoselective conversion of (R)-Amino-(4-chroophenyl) acetic acid is achieved by using an enzyme as a catalyst to obtain the desired chiral product.
Safety information:(R)-Amino-(4-chroophenyl) acetic acid specific safety data is currently not clearly reported. However, in general, appropriate safety measures should be taken when handling chemical reactions, such as wearing appropriate protective equipment (such as gloves, glasses and laboratory coats). At the same time, the treatment of the compound should be carried out in a well-ventilated laboratory environment, avoiding direct contact with the skin and inhalation of gases or dust. If necessary, the operation should be carried out under the guidance of professional personnel.
The properties of the compound are as follows:
Appearance: White crystalline powder
Molecular formula: C8H8ClNO2
Molecular weight: 185.61g/mol
Melting point: 145-150°C
Solubility: Soluble in water and alcohol solvents, insoluble in non-polar solvents
(R)-Amino-(4-chroophenyl) acetic acid is mainly used in the field of medicine. It is a chiral amino acid, which is used as a raw material or stereoselective reagent in the synthesis of drugs, pharmaceutical intermediates and tablets.
The method of preparing (R)-Amino-(4-chlorophenyl)acetic acid can be achieved by the following steps:
1. Synthesis of amino acids: first, the corresponding reaction of 4-chloroacetophenone and phosgene occurs to generate 4-chloroacetophenone. This compound is then reacted with glycine under basic conditions to give the precursor compound of (R)-Amino-(4-chroophenyl) acetic acid.
2. Stereoselective conversion: The stereoselective conversion of (R)-Amino-(4-chroophenyl) acetic acid is achieved by using an enzyme as a catalyst to obtain the desired chiral product.
Safety information:(R)-Amino-(4-chroophenyl) acetic acid specific safety data is currently not clearly reported. However, in general, appropriate safety measures should be taken when handling chemical reactions, such as wearing appropriate protective equipment (such as gloves, glasses and laboratory coats). At the same time, the treatment of the compound should be carried out in a well-ventilated laboratory environment, avoiding direct contact with the skin and inhalation of gases or dust. If necessary, the operation should be carried out under the guidance of professional personnel.
Last Update：2024-04-09 21:11:58
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